Introducing Epigenetics by Cath Ennis

Author:Cath Ennis
Language: eng
Format: epub
ISBN: 9781848319035
Publisher: Icon Books Ltd

ARE YOU SURE THESE PUPS ARE MINE? ABSOLUTELY! IT’S NOT MY FAULT YOU DIDN’T PASS ON YOUR DNA METHYLATION!

Unlike males, female agouti mice produce offspring more like themselves: darker mothers produce greater numbers of methylated, darker, slimmer offspring than do yellow mothers.

Because only the mother’s DNA methylation status affects the next generation, the mechanism could theoretically involve exposures during pregnancy, rather than direct epigenetic inheritance. Perhaps obese, diabetic pregnant mothers provide more sugar, hormones or something else that affects the developing embryos directly.

To rule out this possibility, Australian geneticist Emma Whitelaw took newly fertilized zygotes from dark mothers and implanted them into the wombs of yellow mothers, and vice versa. The methylation status of the biological mother, not the surrogate mother, affected the next generation, providing evidence for the direct inheritance of epigenetic modifications.

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